Publications - Research & Insights by Organo Biotech

Rajasekar, S.; Chakravarty, A.; Jozani, K. A.; Truong, B.; Hendrickson, M.; Attia, A.; Sabouny, M.; Basatskaya, A.; Clotet-Freixas, S.; Ludlow, M.; et al. A High-Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury. Advanced Materials Technologies 2025, 10 (19), e00658. https://doi.org/10.1002/admt.202500658
Marway, M. K.; Bhagentsang, D.; Venugopal, C.; Singh, S. K.; Wylie, R. G.; Zhang, B. Crossing Barriers: In Vitro Cancer Model for Studying Monocyte Migration across Endothelial Barriers. ACS Biomaterials Science & Engineering 2025. https://doi.org/10.1021/acsbiomaterials.5c00783
Kouthouridis, S.; Saha, P.; Ludlow, M.; Truong, B. Y. N.; Zhang, B. Late-stage placenta barrier model for transport studies of prescription drugs during pregnancy. Lab on a Chip 2025. https://doi.org/10.1039/D5LC00075K
Zhang, F.; Jozani, K. A.; Chakravarty, A.; Lin, D.; Hollinger, A.; Rajasekar, S.; Zhang, B. Immune-Infiltrated Cancer Spheroid Model with Vascular Recirculation Reveals Temporally Dependent and Tissue-Specific Macrophage Recruitment. Adv. Healthcare Mater. 2025, 14, 2402946. https://doi.org/10.1002/adhm.202402946
Cariba, S.; Srivastava, A.; Bronsema, K.; Kouthouridis, S.; Zhang, B.; Payne, S. L. Innervated Coculture Device to Model Peripheral Nerve-Mediated Fibroblast Activation. ACS Biomaterials Science & Engineering 2024, 10(20), 7566–7576.
https://doi.org/10.1021/acsbiomaterials.4c01482
Landau, S.; Zhao, Y.; Hamidzada, H.; Kent, G. M.; Okhovatian, S.; Lu, R. X. Z.; Liu, C.; Wagner, K. T.; Cheung, K.; Shawky, S. A.; et al. Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms. Cell Stem Cell (2024). https://doi.org/10.1016/j.stem.2024.05.011
Clotet-Freixas, S. et al. Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease.
Science Translational Medicine 16, eabm2090 (2024). https://doi.org/10.1126/scitranslmed.abm2090
Zhang, F., Lin, D. S. Y., Rajasekar, S., Sotra, A. & Zhang, B. Pump‐Less Platform Enables Long‐Term Recirculating Perfusion of 3D Printed Tubular Tissues. Advanced Healthcare Materials (2023). https://doi.org/10.1002/adhm.202300423
Sotra, A., Jozani, K. A. & Zhang, B. A vascularized crypt-patterned colon model for high-throughput drug screening and disease modelling. Lab on a Chip 23, 3370-3387 (2023). https://doi.org/10.1039/D3LC00211J
Kouthouridis, S. et al. Modeling the Progression of Placental Transport from Early- to Late-Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization. Advanced Healthcare Materials n/a, 2301428 (2023). https://doi.org/10.1002/adhm.202301428
Rajasekar, S. et al. Subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in multi-well plates. Lab on a Chip (2022). https://doi.org/10.1039/D1LC01141C
Rajasekar, S. et al. IFlowPlate—A Customized 384-Well Plate for the Culture of Perfusable Vascularized Colon Organoids. Adv. Mater. 32, 2002974 (2020). https://doi.org/10.1002/adma.202002974
Lin, D. S. Y., Rajasekar, S., Marway, M. K. & Zhang, B. From Model System to Therapy: Scalable Production of Perfusable Vascularized Liver Spheroids in “Open-Top“ 384-Well Plate. ACS Biomaterials Science & Engineering 7, 2964–2972 (2020). https://doi.org/10.1021/acsbiomaterials.0c00236

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